Research efforts of QNMR

An important focus of QNMR is quantitative neuroimaging, which localizes functional specificity of neural ensemble activities. State-of-the-art multi-modal MRI, heteronuclear MRS, electrophysiology and optical imaging methodologies cultivated by on-going efforts of QNMR have created a central role for in vivo rodent brain research in experimental neuroscience. Fundamental results with far reaching implications for brain function shape the research program:

Columnar-level imaging of sensory models
Neurophysiological and neurochemical basis of brain imaging
Quantitative approaches towards interpreting functional imaging data
Energetic costs associated with neuronal and astrocytic functions
Rates of glutamatergic and GABAergic neurotransmission
Relationship between neurotransmission and neuroenergetics

The Program for QNMR is directed by Fahmeed Hyder (Associate Professor, Diagnostic Radiology and Biomedical Engineering). The main resources for QNMR are the high field horizontal-bore magnet systems (4.0T, 9.4T, 11.7T) and the neurophysiology laboratory located at the Magnetic Resonance Research Center (MRRC) at Yale. The QNMR consists of three collaborative research cores:

Core 1: Multi-modal MRI
Core 2: Heteronuclear MRS
Core 3: Electrophysiology and optical imaging
Core 4: Data management